Publications

Cover gallery

Articles (79)

Low-cost, programmable, pressure-based flow controller for multi-channel microfluidics

M. Ernits*, O. Reinsalu, A. Kyritsakis, V. Linko, V. Zadin

SSRN (2024), DOI: 10.2139/ssrn.5008843

Fluorescence Anisotropy Analysis of the Interaction between Doxorubicin and DNA Origami Nanostructures

E. S. Lisitsyna†*, A. Klose†, E. Vuorimaa-Laukkanen, H. Ijäs, T. Lajunen, K. Suhling, V. Linko*, T. Laaksonen*

bioRxiv (2024), 2024.06.20.599777

† Equal contribution authors

Folding of mRNA-DNA origami for controlled translation and viral vector packaging

I. Seitz, S. Saarinen, J. Wierzchowiecka, J. J. L. M. Cornelissen, V. Linko, M. A. Kostiainen*

bioRxiv (2024), 2024.05.29.596417

Controlling Raman enhancement in particle-aperture hybrid nanostructures by interlayer spacing

K. M. Kabusure†, P. Piskunen†, J. J. Saarinen, V. Linko*, T. K. Hakala*

Nanoscale (2024), DOI: 10.1039/D4NR03648D

† Equal contribution authors

Doxorubicin-loaded DNA origami nanostructures: stability in vitreous and their uptake and toxicity in ocular cells

A. Klose*, Z. Gounani, H. Ijäs, T. Lajunen, V. Linko*, T. Laaksonen*

Nanoscale, 16 (2024), 17585-17598

Liposome-based hybrid drug delivery systems with DNA nanostructures and metallic nanoparticles

O. Reinsalu*, M. Ernits, V. Linko*

Expert Opinion on Drug Delivery, 21 (2024), 905-920

Structural stability of DNA origami nanostructures in organic solvents

E. Enlund†, S. Julin†, V. Linko, M. A. Kostiainen*

Nanoscale, 16 (2024), 13407-13415

Cover article of the journal

† Equal contribution authors

Microfluidic production, stability and loading of synthetic giant unilamellar vesicles

M. Ernits, O. Reinsalu, N. Yandrapalli, S. Kopanchuk, E. Moradpur-Tari, I. Sanka, O. Scheler, A. Rinken, R. Kurg, A. Kyritsakis*, V. Linko*, V. Zadin*

Scientific Reports, 14 (2024), #14071

Assembly and optically triggered disassembly of lipid-DNA origami fibers

S. Julin, N. Best, E. Anaya-Plaza, E. Enlund, V. Linko, M. A. Kostiainen*

Chemical Communications, 59 (2023), 14701-14704

DNA-origami-directed virus capsid polymorphism

I. Seitz, S. Saarinen, E.-P. Kumpula, D. McNeale, E. Anaya-Plaza, V. Lampinen, V. P. Hytönen, F. Sainsbury, J. J. L. M. Cornelissen, V. Linko, J. T. Huiskonen*, M. A. Kostiainen*

Nature Nanotechnology, 18 (2023), 1205-1212

Reconfigurable pH-Responsive DNA Origami Lattices

S. Julin, V. Linko*, M. A. Kostiainen*

ACS Nano, 17 (2023), 11014-11022

Stability of DNA Origami Nanostructures in Physiological Media: The Role of Molecular Interactions

V. Linko†*, A. Keller†*

Small, 19 (2023), #2301935

† Equal contribution authors

Raman enhancement in bowtie-shaped aperture-particle hybrid nanostructures fabricated with DNA-assisted lithography

K. M. Kabusure†, P. Piskunen†, J. Yang, V. Linko*, T. K. Hakala*

Nanoscale, 15 (2023), 8589-8596

† Equal contribution authors

Signal Amplification in Electrochemical DNA Biosensors Using Target-Capturing DNA Origami Tiles

P. Williamson, P. Piskunen, H. Ijäs, A. Butterworth, V. Linko*, D. K. Corrigan*

ACS Sensors, 8 (2023), 1471-1480

Supplementary cover article of the journal

Dynamics of DNA Origami Lattices

S. Julin, A. Keller*, V. Linko*

Bioconjugate Chemistry, 34 (2023), 18-29

A label-free light-scattering method to resolve assembly and disassembly of DNA nanostructures

H. Ijäs, T. Liedl, V. Linko*, G. Posnjak*

Biophysical Journal, 121 (2022), 4800-4809

Nanoparticle release from anionic nanocellulose hydrogel matrix

V.-V. Auvinen*, P. Laurén, B. Shen, J. Isokuortti, N. Durandin, T. Lajunen, V. Linko, T. Laaksonen

Cellulose, 29 (2022), 9707-9717

Optically Responsive Protein Coating of DNA Origami for Triggered Antigen Targeting

I. Seitz, H. Ijäs, V. Linko*, M. A. Kostiainen*

ACS Applied Materials & Interfaces, 14 (2022), 38515-38524

Highlighted in Nature Nanotechnology

Nanoswimmers Based on Capped Janus Nanospheres

P. Piskunen†, M. Huusela†, V. Linko†*

Materials, 15 (2022), #4442

† Equal contribution authors

Optical characterization of DNA origami-shaped silver nanoparticles created through biotemplated lithography

K. M. Kabusure†, P. Piskunen†, J. Yang, M. Kataja, M. Chacha, S. Ojasalo, B. Shen, T. K. Hakala*, V. Linko*

Nanoscale, 14 (2022), 9648-9654

Inside front cover article of the journal

† Equal contribution authors

From Precision Colloidal Hybrid Materials to Advanced Functional Assemblies

V. Linko, H. Zhang, Nonappa*, M. A. Kostiainen*, O. Ikkala*

Accounts of Chemical Research, 55 (2022), 1785-1795

Cover article of the journal

Integrating CRISPR/Cas systems with programmable DNA nanostructures for delivery and beyond

P. Piskunen, R. Latham, C. E. West, M. Castronovo*, V. Linko*

iScience, 25 (2022), #104389

Environment-Dependent Stability and Mechanical Properties of DNA Origami Six-Helix Bundles with Different Crossover Spacings

Y. Xin, P. Piskunen, A. Suma, C. Li, H. Ijäs, S. Ojasalo, I. Seitz, M. A. Kostiainen, G. Grundmeier, V. Linko*, A. Keller*

Small, 18 (2022), #2107393

Engineering Inorganic Materials with DNA Nanostructures

A. Heuer-Jungemann†*, V. Linko†*

ACS Central Science, 7 (2021), 1969-1979

† Equal contribution authors

Prospective Cancer Therapies Using Stimuli-Responsive DNA Nanostructures

I. Seitz†, A. Shaukat†, K. Nurmi†, H. Ijäs, J. Hirvonen, H. A. Santos, M. A. Kostiainen*, V. Linko*

Macromolecular Bioscience, 21 (2021), #2100272

† Equal contribution authors

Probing the Conformational States of a pH-Sensitive DNA Origami Zipper via Label-Free Electrochemical Methods

P. Williamson†, H. Ijäs†, B. Shen, D. K. Corrigan*, V. Linko*

Langmuir, 37 (2021), 7801-7809

† Equal contribution authors

Hybrid Nanoassemblies from Viruses and DNA Nanostructures

S. Ojasalo†, P. Piskunen†, B. Shen, M. A. Kostiainen*, V. Linko†*

Nanomaterials, 11 (2021), #1413

† Equal contribution authors

Scaling Up DNA Origami Lattice Assembly

Y. Xin, B. Shen, M. A. Kostiainen, G. Grundmeier, M. Castro, V. Linko*, A. Keller*

Chemistry-A European Journal, 27 (2021), 8564-8571

Frontispiece of the journal

Unraveling the interaction between doxorubicin and DNA origami nanostructures for customizable chemotherapeutic drug release

H. Ijäs, B. Shen, A. Heuer-Jungemann, A. Keller, M. A. Kostiainen, T. Liedl, J. A. Ihalainen, V. Linko*

Nucleic Acids Research, 49 (2021), 3048-3062

Engineered protein cages for selective heparin encapsulation

S. Välimäki†, Q. Liu†, L. Schoonen, D. F. M. Vervoort, Nonappa, V. Linko, R. J. M. Nolte, J. C. M. van Hest, M. A. Kostiainen*

Journal of Materials Chemistry B, 9 (2021), 1272-1276

Cover article of the journal

† Equal contribution authors

Biotemplated Lithography of Inorganic Nanostructures (BLIN) for Versatile Patterning of Functional Materials

P. Piskunen†, B. Shen†, A. Keller, J. J. Toppari, M. A. Kostiainen*, V. Linko*

ACS Applied Nano Materials, 4 (2021), 529-538

Supplementary cover article of the journal

† Equal contribution authors

DNA-Origami-Templated Growth of Multilamellar Lipid Assemblies

S. Julin, Nonappa, B. Shen, V. Linko*, M. A. Kostiainen*

Angewandte Chemie International Edition, 60 (2021), 827-833

Advanced DNA Nanopore Technologies

B. Shen†, P. Piskunen†, S. Nummelin, Q. Liu, M. A. Kostiainen, V. Linko*

ACS Applied Bio Materials, 3 (2020), 5606-5619

† Equal contribution authors

Robotic DNA Nanostructures

S. Nummelin, B. Shen, P. Piskunen, Q. Liu, M. A. Kostiainen*, V. Linko*

ACS Synthetic Biology, 9 (2020), 1923-1940

Supplementary cover article of the journal

De novo nanomaterial crystals from DNA frameworks

V. Linko*, M. A. Kostiainen*

Nature Materials, 19 (2020), 706-707

News and Views commentary on the work by O. Gang and colleagues

Phthalocyanine-DNA origami complexes with enhanced stability and optical properties

A. Shaukat, E. Anaya-Plaza, S. Julin, V. Linko, T. Torres*, A. de la Escosura*, M. A. Kostiainen*

Chemical Communications, 56 (2020), 7341-7344

Aptamer-embedded DNA origami cage for detecting (glycated) hemoglobin with a surface plasmon resonance sensor

S. Duanghathaipornsuk†, B. Shen†, B. D. Cameron†, H. Ijäs, V. Linko, M. A. Kostiainen, D.-S. Kim*

Materials Letters, 275 (2020), #128141

† Equal contribution authors

Increasing Complexity in Wireframe DNA Nanostructures

P. Piskunen†, S. Nummelin†, B. Shen, M. A. Kostiainen, V. Linko†*

Molecules, 25 (2020), #1823

† Equal contribution authors

Challenges and Perspectives of DNA Nanostructures in Biomedicine

A. Keller†*, V. Linko†*

Angewandte Chemie International Edition, 59 (2020), 15818-15833

† Equal contribution authors

At the Dawn of Applied DNA Nanotechnology

V. Linko*

Molecules, 25 (2020), #639

Invited editorial of the Special Issue

Serum Albumin-Peptide Conjugates for Simultaneous Heparin Binding and Detection

Q. Liu, S. Välimäki, A. Shaukat, B. Shen, V. Linko, M. A. Kostiainen*

ACS Omega, 4 (2019), 21891-21899

DNA Origami-Mediated Substrate Nanopatterning of Inorganic Structures for Sensing Applications

P. Piskunen, B. Shen, S. Julin, H. Ijäs, J. J. Toppari, M. A. Kostiainen, V. Linko*

Journal of Visualized Experiments, (151) (2019), e60313

Real-Time Observation of Superstructure-Dependent DNA Origami Digestion by DNase I Using High-Speed Atomic Force Microscopy

S. Ramakrishnan†, B. Shen†, M. A. Kostiainen, G. Grundmeier, A. Keller*, V. Linko*

ChemBioChem, 20 (2019), 2818-2823

† Equal contribution authors

Cover feature article of the journal (with a video abstract)

Halogen-Bond-Mediated Self-Assembly of Polymer-Resorcinarene Complexes

S. Välimäki, L. Gustavsson, N. K. Beyeh*, V. Linko, M. A. Kostiainen*

Macromolecular Rapid Communications, 40 (2019), #1900158

Reconfigurable DNA Origami Nanocapsule for pH-Controlled Encapsulation and Display of Cargo

H. Ijäs, I. Hakaste, B. Shen, M. A. Kostiainen, V. Linko*

ACS Nano, 13 (2019), 5959-5967

DNA origami directed 3D nanoparticle superlattice via electrostatic assembly

S. Julin, A. Korpi, Nonappa, B. Shen, V. Liljeström, O. Ikkala, A. Keller, V. Linko*, M. A. Kostiainen*

Nanoscale, 11 (2019), 4546-4551

Structural stability of DNA origami nanostructures under application-specific conditions

S. Ramakrishnan, H. Ijäs, V. Linko*, A. Keller*

Computational and Structural Biotechnology Journal, 16 (2018), 342-349

DNA Origami Nanophotonics and Plasmonics at Interfaces

B. Shen, M. A. Kostiainen, V. Linko*

Langmuir, 34 (2018), 14911-14920

Supplementary cover article of the journal

Superstructure-Dependent Loading of DNA Origami Nanostructures with a Groove-Binding Drug

F. Kollmann, S. Ramakrishnan, B. Shen, G. Grundmeier, M. A. Kostiainen, V. Linko*, A. Keller*

ACS Omega, 3 (2018), 9441-9448

Dynamic DNA Origami Devices: from Strand-Displacement Reactions to External-Stimuli Responsive Systems

H. Ijäs†, S. Nummelin†, B. Shen†, M. A. Kostiainen, V. Linko*

International Journal of Molecular Sciences, 19 (2018), #2114

† Equal contribution authors

A supramolecular host-guest complex for heparin binding and sensing

S. Välimäki, N. K. Beyeh, V. Linko, R. H. A. Ras, M. A. Kostiainen*

Nanoscale, 10 (2018), 14022-14030

On the Stability of DNA Origami Nanostructures in Low-Magnesium Buffers

C. Kielar†, Y. Xin†, B. Shen, M. A. Kostiainen, G. Grundmeier, V. Linko*, A. Keller*

Angewandte Chemie International Edition, 57 (2018), 9470-9474

† Equal contribution authors

"Hot Paper" of the journal

DNA nanostructure-directed assembly of metal nanoparticle superlattices

S. Julin†, S. Nummelin†, M. A. Kostiainen*, V. Linko*

Journal of Nanoparticle Research, 20 (2018), #119

† Equal contribution authors

Plasmonic nanostructures through DNA-assisted lithography

B. Shen†, V. Linko†, K. Tapio, S. Pikker, T. Lemma, A. Gopinath, K. V. Gothelf, M. A. Kostiainen*, J. J. Toppari*

Science Advances, 4 (2018), eaap8978

† Equal contribution authors

Evolution of Structural DNA Nanotechnology

S. Nummelin, J. Kommeri, M. A. Kostiainen*, V. Linko*

Advanced Materials, 30 (2018), #1703721

Inside back cover article of the journal

Nanometrology and super-resolution imaging with DNA

E. Graugnard*, W. L. Hughes*, R. Jungmann*, M. A. Kostiainen*, V. Linko*

MRS Bulletin, 42 (2017), 951-959

Protein Coating of DNA Nanostructures for Enhanced Stability and Immunocompatibility

H. Auvinen, H. Zhang, Nonappa, A. Kopilow, E. H. Niemelä, S. Nummelin, A. Correia, H. A. Santos, V. Linko*, M. A. Kostiainen*

Advanced Healthcare Materials, 6 (2017), #1700692

Cover article of the journal

DNA origami structures as calibration standards for nanometrology

V. Korpelainen*, V. Linko, J. Seppä, A. Lassila, M. A. Kostiainen

Measurement Science and Technology, 28 (2017), #034001

Cellular delivery of enzyme-loaded DNA origami

A. Ora†, E. Järvihaavisto†, H. Zhang, H. Auvinen, H. A. Santos, M. A. Kostiainen*, V. Linko*

Chemical Communications, 52 (2016), 14161-14164

† Equal contribution authors

Automated design of DNA origami

V. Linko*, M. A. Kostiainen*

Nature Biotechnology, 34 (2016), 826-827

News and Views commentary on the work by M. Bathe and colleagues

Metallic Nanostructures Based on DNA Nanoshapes

B. Shen*, K. Tapio, V. Linko, M. A. Kostiainen, J. J. Toppari*

Nanomaterials, 6 (2016), #146

DNA-Based Enzyme Reactors and Systems

V. Linko*, S. Nummelin, L. Aarnos, K. Tapio, J. J. Toppari, M. A. Kostiainen*

Nanomaterials, 6 (2016), #139

Cationic polymers for DNA origami coating - examining their binding efficiency and tuning the enzymatic reaction rates

J. K. Kiviaho†, V. Linko†, A. Ora, T. Tiainen, E. Järvihaavisto, J. Mikkilä, H. Tenhu, Nonappa, M. A. Kostiainen*

Nanoscale, 8 (2016), 11674-11680

† Equal contribution authors

One-step large-scale deposition of salt-free DNA origami nanostructures

V. Linko, B. Shen, K. Tapio, J. J. Toppari, M. A. Kostiainen*, S. Tuukkanen*

Scientific Reports, 5 (2015), #15634

DNA Nanostructures as Smart Drug-Delivery Vehicles and Molecular Devices

V. Linko, A. Ora, M. A. Kostiainen*

Trends in Biotechnology, 33 (2015), 586-594

Self‐Assembly of Amphiphilic Janus Dendrimers into Mechanically Robust Supramolecular Hydrogels for Sustained Drug Release

S. Nummelin, V. Liljeström, E. Saarikoski, J. Ropponen, A. Nykänen, V. Linko, J. Seppälä, J. Hirvonen, O. Ikkala, L. M. Bimbo*, M. A. Kostiainen*

Chemistry-A European Journal, 21 (2015), 14433-14439

Custom-shaped metal nanostructures based on DNA origami silhouettes

B. Shen†, V. Linko†, K. Tapio, M. A. Kostiainen*, J. J. Toppari*

Nanoscale, 7 (2015), 11267-11272

† Equal contribution authors

A modular DNA origami-based enzyme cascade nanoreactor

V. Linko†, M. Eerikäinen†, M. A. Kostiainen*

Chemical Communications, 51 (2015), 5351-5354

† Equal contribution authors

Dielectrophoretic trapping of multilayer DNA origami nanostructures and DNA origami-induced local destruction of silicon dioxide

B. Shen†, V. Linko†, H. Dietz, J. J. Toppari*

Electrophoresis, 36 (2015), 255-262

Cover article of the journal

† Equal contribution authors

Virus-Encapsulated DNA Origami Nanostructures for Cellular Delivery

J. Mikkilä, A.-P. Eskelinen, E. H. Niemelä, V. Linko, M. J. Frilander, P. Törmä, M. A. Kostiainen*

Nano Letters, 14 (2014), 2196-2200

Ionic Permeability and Mechanical Properties of DNA Origami Nanoplates on Solid-State Nanopores

C. Plesa, A. N. Ananth, V. Linko, C. Gülcher, A. J. Katan, H. Dietz, C. Dekker*

ACS Nano, 8 (2014), 35-43

Highlighted by the journal's editor

The enabled state of DNA nanotechnology

V. Linko, H. Dietz*

Current Opinion in Biotechnology, 24 (2013), 555-561

Self-Assembled DNA-Based Structures for Nanoelectronics

V. Linko*, J. J. Toppari*

Journal of Self-Assembly and Molecular Electronics (SAME), 1 (2013), 101-124

Cover article of the journal

Growth of immobilized DNA by polymerase: bridging nanoelectrodes with individual dsDNA molecules

V. Linko*, J. Leppiniemi, B. Shen, E. Niskanen, V. P. Hytönen, J. J. Toppari

Nanoscale, 3 (2011), 3788-3792

ALD Grown Aluminum Oxide Submonolayers in Dye-Sensitized Solar Cells: The Effect on Interfacial Electron Transfer and Performance

L. J. Antila, M. J. Heikkilä, V. Mäkinen, N. Humalamäki, M. Laitinen, V. Linko, P. Jalkanen, J. Toppari, V. Aumanen, M. Kemell, P. Myllyperkiö, K. Honkala, H. Häkkinen, M. Leskelä, J. E. I. Korppi-Tommola*

The Journal of Physical Chemistry C, 115 (2011), 16720-16729

Defined-size DNA triple crossover construct for molecular electronics: modification, positioning and conductance properties

V. Linko†*, J. Leppiniemi†, S.-T. Paasonen†, V. P. Hytönen, J. J. Toppari

Nanotechnology, 22 (2011), #275610

† Equal contribution authors

Field‐Induced Nanolithography for High‐Throughput Pattern Transfer

T. K. Hakala, V. Linko, A.-P. Eskelinen, J. J. Toppari, A. Kuzyk, P. Törmä*

Small, 5 (2009), 2683-2686

Inside cover article of the journal

Characterization of the Conductance Mechanisms of DNA Origami by AC Impedance Spectroscopy

V. Linko, S.-T. Paasonen, A. Kuzyk, P. Törmä, J. J. Toppari*

Small, 5 (2009), 2382-2386

Dielectrophoretic Trapping of DNA Origami

A. Kuzyk*, B. Yurke, J. J. Toppari, V. Linko, P. Törmä

Small, 4 (2008), 447-450

Book chapters (5)

Surface assisted methods

P. Piskunen, A. Keller*, V. Linko*

in The Art of Molecular Programming. World Scientific (2025), in press

Protein Coating of DNA Origami

H. Ijäs, M. A. Kostiainen*, V. Linko*

in DNA and RNA Origami: Methods and Protocols. Series: Methods in Molecular Biology, Vol. 2639, pp. 195-207 Editor: J. Valero, Series Editor: J. M. Walker. Humana Press, Springer Science+Business Media New York (2023), ISBN 978-1-0716-3027-3

Assembly of Nanoparticle Superlattices Using DNA Origami as a Template

S. Julin, P. Piskunen, M. A. Kostiainen*, V. Linko*

in DNA Origami: Structures, Technology, and Applications, 1st edition, pp. 155-166. Editor: M. Endo. John Wiley & Sons, Inc. (2022), ISBN 978-1-1196-8254-7

DNA-Assisted Molecular Lithography

B. Shen, V. Linko, J. J. Toppari*

in DNA Nanotechnology: Methods and Protocols, 2nd Edition. Series: Methods in Molecular Biology, Vol. 1811, pp. 299-314. Editor: G. Zuccheri, Series Editor: J. M. Walker. Humana Press, Springer Science+Business Media New York (2018), ISBN 978-1-4939-8581-4

Packaging DNA Origami into Viral Protein Cages

V. Linko, J. Mikkilä, M. A. Kostiainen*

in Virus-Derived Nanoparticles for Advanced Technologies: Methods and Protocols. Series: Methods in Molecular Biology, Vol. 1776, pp. 267-277. Editors: C. Wege and G. P. Lomonossoff, Series Editor: J. M. Walker. Humana Press, Springer Science+Business Media New York (2018), ISBN 978-1-4939-7806-9